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BD 流式检测试剂盒 560751 Human Th1/Th2/Th17 Phenotyping Kit英文名称:

BD  流式检测试剂盒 560751 Human Th1/Th2/Th17 Phenotyping Kit
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产品描述

产品英文名称:Human Th1/Th2/Th17 Phenotyping Kit
产品中文名称:流式检测试剂盒

 


BD 560751 流式检测试剂盒 Human Th1/Th2/Th17 Phenotyping Kit 简介:
Catalog Number  560751
Brand  BD Pharmingen™
Name  Human Th1/Th2/Th17 Phenotyping Kit
Contents  Human Th1/Th2/Th17 Phenotyping Cocktail (CD4 PerCP-Cy™5.5, IL-17A PE, IFN-γ FITC, IL-4 APC), BD Cytofix™ Fixation Buffer, BD Perm/Wash™ Buffer, BD GolgiStop™ Protein Transport Inhibitor
Size  50 Tests
Regulatory Status  RUO
Related Molecules  IL4 CD4 IFNG IL17A   


BD 560751 流式检测试剂盒介绍:
外围CD4+ T细胞池包括通过抗原驱动出现多效应和记忆T细胞亚群膨胀和幼稚T细胞的分化。幼稚的CD4 + T细胞对抗原刺激的早期应答的特征在于通过高水平的增殖和细胞因子有限剧目。进一步分化产生细胞与更多样化的潜力因素的影响,1型T辅助细胞(Th1),由免疫反应产生的Th2,Th17细胞和效应器和/或存储器单元。功能上偏振的CD4 + T细胞亚群已被确定的基础上的细胞因子分泌的其独特的图案。作为
签名的细胞因子,Th1细胞选择性地产生大量的干扰素-γ(IFN-γ)的。 Th2细胞选择性产生IL-4,和Th17表达高水平的IL-17A的。通过IFN-γ和其他效应分子的分泌,Th1细胞激活巨噬细胞,自然杀伤(NK)细胞和CD8 + T细胞,并负责细胞介导的​​免疫。 Th1细胞提供防止细胞内的细菌,真菌,原生动物和病毒,并参与某些自身免疫应答。 IL-4的
由Th2细胞产生特别强的驱动B细胞产生IgE的分泌细胞。 IgE水平起着嗜碱性粒细胞/肥大作用细胞介导的​​免疫反应。 Th2细胞介导防范外寄生虫还可​​能导致有害过敏响应速度发展。通过IL-17A和其他因素的分泌,Th17细胞招募和激活嗜中性粒细胞和介导针对细胞外细菌和真菌的免疫应答。 Th17细胞也被牵连自身免疫应答。在除了这些类型的T辅助细胞,Th0-(IL-4和IFN-γ)和Th17 / Th1细胞样(IL-17A / IFN-γ)的细胞共表达签名
细胞因子已被描述。在Th1 / Th2细胞/ Th17细胞的范式提供了一个有用的模型系统研究细胞和分子机制调解保护以及有害的免疫应答。在BD人Th1 / Th2细胞/ Th17细胞表型套件提供了一个易于使用的四色荧光的鸡尾酒抗体特异性针对人CD4,IFN-γ(Th1细胞对),IL-(Th2细胞)和IL-17A(对于Th17细胞) - 即将使研究人员能够识别和多色流量检定这些T辅助细胞类型的性质流式细胞分析。该试剂盒可用于成功地分析体外淋巴细胞的细胞样品(例如,在类型
体内产生的人外周血T辅助细胞)或通过细胞内的各种培养并监控T辅助细胞分化实验模型系统。调查人员应注意的是BD GolgiStop™蛋白转运抑制剂的外观可能不清楚各种颜色(无色)到浅黄色。


BD  流式检测试剂盒 560751英文描述:
The peripheral CD4+ T cell pool includes multiple effector and memory T cell subsets that arise through antigen-driven expansion and differentiation of naïve T cells. The early response of naïve CD4+ T cells to antigenic stimulation is characterizedby high level proliferation and a limited cytokine repertoire. Further differentiation yields cells with a more diverse potential for
cytokine expression. Depending upon the balance of local cytokines, costimulatory molecules, antigen levels, and genetic factors, Type-1 T helper (Th1), Th2, and Th17 effector and/or memory cells are generated by immune responses.
Functionally-polarized CD4+ T cell subsets have been identified based on their distinctive patterns of cytokine secretion. As a signature cytokine, Th1 cells selectively produce large amounts of interferon-gamma (IFN-γ). Th2 cells selectively produce IL-4,and Th17 express high levels of IL-17A. Through secretion of IFN-γ and other effector molecules, Th1 cells activate macrophages, natural killer (NK) cells, and CD8+ T cells and are responsible for cell-mediated immunity. Th1 cells provide protection against intracellular bacteria, fungi, protozoa and viruses and are involved in some autoimmune responses. IL-4 produced by Th2 cells is particularly strong in driving B cells to generate IgE-secreting cells. IgE plays a role in basophil/mast cell mediated immune reactions. Th2 cells mediate protection against extracellular parasites but may also cause harmful allergic responsiveness to develop. Through the secretion of IL-17A and other factors, Th17 cells recruit and activate neutrophils and mediate immune responses against extracellular bacteria and fungi. Th17 cells are also implicated in autoimmune responses. In addition to these types of T helper cells, Th0- (IL-4 and IFN-γ) and Th17/Th1-like (IL-17A/IFN-γ) cells that coexpress signature cytokines have been described.
The Th1/Th2/Th17 paradigm provides a useful model system for investigating the cellular and molecular mechanisms that mediate protective as well as harmful immune responses. The BD Human Th1/Th2/Th17 Phenotyping Kit provides an easy-to-use four-color cocktail of fluorescent antibodies-specific for human CD4, IFN-γ (for Th1), IL-4 (for Th2) and IL-17A (for Th17)-that will enable researchers to identify and characterize the nature of these T helper cell types by multicolor flow cytometric analysis. The kit can be used to successfully analyze ex vivo lymphoid cell samples (eg, for the types of in vivo-generated human peripheral blood T helper cells) or to monitor T helper cell differentiation by cells cultured within various experimental model systems.
Investigators should note that the appearance of BD GolgiStop™ Protein Transport Inhibitor may range in color from clear (colorless) to light yellow.
 

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BD 流式检测试剂盒 560751 Human Th1/Th2/Th17 Phenotyping Kit

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